Having two forms of estrogen compounded together has worked so much better than using the straight estradiol patch. The estradiol in the patch is way too strong for me even at the lowest dose. On the patch, my ovaries ache and throb from developing cysts. The compounded estrogen has a partial mixture of estradiol and a weaker estrogen called estriol. This combination resolves my menopause symptoms without causing ovarian pain and cysts. Please do not take this option away from those of us who depend on a customized compounded prescription.