I have used only bio-identical homones for years, ever since I developed issues in menopause. The compounding pharmacy is able to make troches with the exact formula that my body needs. My doctor provides testing to check levels and make adjustments as needed. I have had no issues with the hormones I've been taking for years. They work well providing exactly what my body needs.
I have never tried the artificial hormones as I feel they are just that - artificial. With the bio-identical, I am able to get all the hormones I need, not just estrogen.