For years I tried the standard medicine for pre-menopausal symptoms, as well as herbs, etc. from health food stores. No help to me. Finally, quite a few years after menopause, I found a new doctor who encouraged me to try compounding hormone therapy. I am now able to live a normal life- no hot flashes, no night sweats; I have a balanced life. I am able to keep my levels - testosterone, progesterone, estrogen, dhea, thyroid - all at optimal levels! So glad I found compounding!