For several different reasons, including chronic stress and sever allergies, my immune system was depleted. I had unexplained weight loss and hair loss, as well as a number of digestive issues, and a lot of fatigue. After determining I was a good candidate for hormone support, I felt like a regular person again! My energy was back and I could make it through the day without a nap. My fibroids and endometriosis have held steady, allowing me to avoid surgery. I am very grateful for the compounding formulas, so that I can avoid the synthetic hormones that did not work for me. If synthetic was my only choice, I likely wouldn't be able to take them, and my health would once again be jeopardized.