In 2006 I was seriously depressed, could hardly get off the couch. Wellbutrin and Zoloft were ineffective. After two weeks on a 50 mg bio-identical compounded progesterone, my depression was gone, because progesterone deficiency was the cause of my depression so replacing it was the only solution. I'm chemically sensitive so I avoid conventional pharmaceuticals and their side effects. I have not had a hypersensitivity reaction to and absolutely zero side effects of bio-identical compounded hormone replacement therapy in the 16 years that I've been taking them. With BHRT, symptoms indicate a need for dosage adjustment only. After menopause, I added estradiol. I am one of the few perimenopausal women I know who sleeps well all the way until morning because I have enough progesterone, don't gain weight because I have enough progesterone, am continent of urine because I have enough estradiol, and have full cognitive functioning, few wrinkles, an physically active life, and good muscle mass and skin thickness because my hormones are balanced as stably as pre-menopause. Hormonal balance is evidence-based as crucial to male and to female health because hormones affect the entire body. PCPs and Gynecologists need to promote bio-identical hormone replacement therapy (BHRT) for most of what ails women. I seemed to need progesterone for heavy bleeding and for depression as early as my teen and my young adult years.