For 15+ years and counting I have been on E and P. My heart, brain, bones, etc. have not declined but increased in health as per my lab tests. I would encourage all women post-menopause to use these Rx instead of heart meds, brain meds, and bone meds. Natural therapy is the way to go. Wiley Protocol is my method of health. I am on no other meds at 71 years old.