Everyone thinks as women we tend to go through hot flashes and feeling completely moody all the time. With the hormone replacement I feel like I'm 30 all of the time. When I run out, my hot flashes start up and I become irritable and hard to deal with. Can you imagine all the women in the world running around without their hormone replacement? It would set us back to the dark ages. If this works then why take it off the market? This is EXTREMELY important to the quality of life. Men don't really have to worry about this. Why punish the women?