I have several medical diagnoses which were exacerbated severely, along with completely new sets of symptoms, with the onset of menopause. At least one of my conditions is reliant on the activity of estrogen and progesterone. My labs showed severe deficiency in both. I was trying to manage my already known health conditions, work full time and deal with all the symptoms of menopause (including lack of sleep) at the same time. An MD prescribed transdermal/topical Bioidentical HRT. Within 3 months my body responded and I was back to feeling and operating close to my usual baseline. Symptoms improved even more after 6 mos. Please do not take compounding Bioidentical HRT away from us. There are so many that can not function as a healthy human without it.