After a complete (unneeded) hysterectomy at 50, and then 15 years on patches, injections & Premarin. Life was hell. At 65, I took a combination troche from a compounding pharmacy and there was such an improvement. It took 2 years of more blood tests every 6 months to reach perfection. At 75, I'm the healthiest I've ever been. I can't go back because a federal bureaucrat, sitting in an office, makes a decision about me, without taking my situation into account.