I had a hysterectomy in 1995 and had horrible arthritis as a result. I was advised to use Premarin but they made my throat close up. I was put on patches etc but they did not work. Finally, my GYN recommended compounded hormones. I've used them ever since. A few attempts at cutting back or stopping have resulted in inflammation and arthritis so bad that I could not walk. Why would you want to stop such a useful and well-researched medication?