I had to start taking hormone replacement therapy 1yr ago. The lowest strength estradiol supplement is a transdermal patch and it releases 0.0375mg/24 hours. The patch is changed every 3 days. I was allergic to the adhesive in the patch and it caused a red / itchy rash all around where the patch was applied on my skin. There were no tablets in mg size small enough to replace the patch. So, compounding my prescription was the only choice. I now have a transdermal cream and 1ml / 1 pump has 0.0375mg that I apply daily. It works great. Please do not stop the production of compounded hormone replacement medications.