Chemotherapy threw me into sudden menopause when I was only early 40's. Symptoms were almost unbearable - painful vaginal dryness, urinary tract infections, and zero libido. My doctor resisted hormones because I'd previously had cancer. When she finally gave in to my plea for relief, she prescribed Premarin. I'd read that Premarin and similar products are made with Estradiol and/or Estrone which carry a risk of cancer so I decided against it and continued to suffer. Eventually, I found a doctor who knew about compounded hormones which can be made with Estriol, a safer form of estrogen for women like me who've had cancer. I have now used it safely for almost 20 years and what an incredible difference it has made in my quality of life!