Being in my 60s, I've taken cBHT now for half of my life. For financial reasons only, had I needed to stop taking them for a while & during those times I'd have likely preferred death, due to the often times severe pain my body was in (arthritis, etc), feeling very ill with no energy. Upon being back on my cBHT, all those symptoms were gone within a week, and even my skin which had badly thinned, became healthier again, within 2 weeks. I have friends who had taken synthetic HRT, and each are suffering for it now. And I have family & friends using cBHT, like me, & opinions on this side are that we'd rather be put in front of a firing squad, than be forced to give up our compounded bioidentical hormones. One size/type fits all meds. does not work for anyone!