I am 80 years old and have had severe, debilitating hot flashes and night sweats since 1996 and the only thing that has given me relief is bio-identical hormones. Through the years I have tried to go off the two times and the hot flashes and night sweat returned with a vengeance. The night sweats were so bad that My body, clothing, and bed would be soaking wet. I suspect that I will need the bio-identical hormones for the remainder of my life as nothing else had made a difference.