Before I started this hormone replacement therapy, I had become a mess. The lack of a full night's sleep for a very long period of time had really worn my body out. I was having short term memory loss, was very irritable, and feeling tired constantly. Since starting my meds, all the issues I was having to deal with are extremely better. And best of all, I only take the strength that I need. We had to adjust a couple of times but it works great for me now.