After a hysterectomy in my early 40's, I was prescribed Premarin. I had no problems for a few years, then began to have hot flashes and night sweats, with some mood swings. My doctor then had my hormones checked, and prescribed topical hormone therapy. It made all the difference. No more flashes or sweats. I am now 84 years old, and continuing with the therapy. People usually think that I am much younger. I'm active and healthy. My prescription has been adjusted from time to time. I would not ever want to stop using it.