After 40 years (After radical hysterectomy) of suffering the effects of not having any hormones at all. Years of doctors guessing what closes of Premarin, frog, skin, and tester one. some had to give me enough to have a stroke. This is due to fact that no blood tests even being taken to see what my levels were. Then FOA decides hormone replacement was bad for the heart and doctors took patients off hormones. Bioidentical hormones with a blood test for your levels needed always seemed best but till about 10 years ago I couldn't find doctors. Since I have ruined my life!