I have used natural hormone therapy since 1999. My cystic breast disease went away after starting progesterone. I have had no hot flashes. My energy to exercise is still good. I can run/walk a 12 minute mile at age 67. Have not had any breast cancer or uterine cancer. After getting my hormones balanced, my thyroid levels balanced out. I use a compounded progesterone cream and an estriol/estradiol cream. Have no heart disease or high cholesterol. Since estrogen falls in menopause but progesterone falls more, I need both to be well and feel well.